Sondy SureFISH są projektowane komputerowo i chemicznie syntetyzowane za pomocą biblioteki nukleotydów (OLS). Pozwala to na zniesienie ograniczeń narzucanych przez technologię syntezy sond z użyciem sztucznego chromosomu bakteryjnego (BAC). Agilent jest jedynym dostawcą, który nie posiada w swym portfolio sond FISH produkowanych z użyciem technologii BAC.
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